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H042

Xanthotoxin, 99%

CAS number

298-81-7

 


 

Molecular formula

C12H8O4

 

Molecular weight

216.19

 

mp

148-150 °C

 

Price and availability

25 mg

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100 mg

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500 mg


Synomym

Methoxysalen; 8-Methoxypsoralen; 8-MOP; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; Ammoidin; Meladinin

Product information

Xanthotoxin is a Furocoumarin found in several different plants, especially Psoralea corylifolia. It is used to increase skin pigmentation with sunlight in the treatment of depigmentation conditions such as vitiligo and may cause skin burns and liver damage. Xanthotoxin plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. Xanthotoxin is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+]. Potent inhibitor of coumarin7-hydrolase (COH) activity in mice in vivo and also in human liver microsomes.

Safety

Hazard. Xn (harmful)
Risk. Harmful if swallowed. May cause sensitisation by skin contact.
Safety Statement. Wear suitable protective clothing and gloves.

References

Loutfy, M.A. et al., Anal. Profiles Drug Subst. 1980, 9, 455.
Tessman, J.W. et al. Biochem. 1985, 24, 1669.
Maenpaa, J. et al., Biochem. Pharmacol. 1993, 45, 5, 1035-1042.
Diawara, M.M. et al., J. Biochem Mol. Toxicol. 1999, 13, (3-4), 195-203.