H068

Sphondin, 99%

CAS number

483-66-9

Molecular formula

C₁₂H₈O₄

Molecular weight

216.19

mp

Price and availability

25 mg

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100 mg

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500 mg

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Synomym

6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one; 2H-Furo(2,3-h)-1-benzopyran-2-one,6-methoxy-

Product information

A furanocoumarin derivative isolated from Heracleum laciniatum. Cause of phototoxicity in patient with vitiligo. Potent inhibitor of mouse coumarin7-hydrolase (COH) activity. Possess an inhibitory effect on IL-1b-induced COX-2 protein expression and PGE2 release in human pulmonary epithelial cell line (A549).

Safety

References

Kavli, G., et al., Contact Dermatitis, 1983, 9, 5, 365-366.
Maenpaa, J. et al., Biochem. Pharmacol. 1993, 45, 5, 1035-1042.
Yang, L-L. et al. Life Sciences 2002, 72, 199-213.