H105

Imperatorin, 99%

CAS number

482-44-0

Molecular formula

C₁₆H₁₄O₄

Molecular weight

270.29

mp

102 °C (lit.)

Price and availability

25 mg

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100 mg

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500 mg

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Synomym

Ammidin; Marmelosin; Pentosalen;
8-Isopentenyloxypsoralen; 7H-Furo(3,2-g)(1)benzopyran-7-one,9((3-methyl-2-butenyl)oxy)-

Product information

Naturally occurring furocoumarin from Angelica dahurica Benth et Hook, West African medicinal plant Clausena anisata and other plants. Inhibits HIV-1 replications through an Sp1-dependent pathway. Induce hepatic GSTs and potent inhibitor of P450 1A1/1B1. Tumor necrosis factor antagonist. In human lymphocyte cultures Imperatorin successively inhibited and accelerated cell proliferation. It showed slight clastogenic effect, the chromosome-damaging effect being expressed mainly in a doubling of the break rate. Shows hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Shows chemopreventive effects when administered orally on skin tumor initiation by 7,12-dimethylbenz[a]anthracene (DMBA). Activate adrenaline-induced lipolysis and activate ACTH-induced lipolysis.

Safety

References

Abel, G. et al. Planta Med., 1981, 42, 4, 333.
Oh, H. et al., Planta Med. 2002, 68, 5, 463-464.
Kleiner, H.E. Chem. Res. Toxicol. 2002, 15, 2, 226-235.
Kleiner, H.E. Carcinogenesis 2002, 23, 10, 1667-1675.
Sancho, R. et al.The Journal of Biological Chemistry 2004, 279, 36’ 37349-3759.
Kimura, Y. et al. Planta Med., 1988, 45, 183-187.